Software
Used: Adobe Photoshop 4.0, Laurie
McCanna's Design Brush set.
1.) Click the link above to download Laurie McCanna's Custom Design Brushes, then follow her instructions for loading them into Photoshop's brush palette. (Continued below...)
2.) Set your background color to a shade of light pink and your foreground
color to white. 
3.) Open a new image, 200 by 200 pixels, 72 dpi. Under contents, make sure that background color is selected. This should give you a pink-filled square. Resize the image window so that there is about an inch of gray area on the top and bottom of the image.
4.) Next we want to add some noise and a Gaussian blur to soften it. Go to Filter -> Noise -> Add Noise and use the settings in my example below. Next go to Filter -> Blur -> Gaussian Blur and use a radius of 0.5 pixels.
5.) Select the brush tool and choose the brush from Laurie McCanna's
design brushes. It is the one outlined in red in my screen shot. 
In the paintbrush options, set the opacity to about 50%.
6.) Make sure you have rulers showing (Ctrl-R) and from the rulers drag out four guidelines in the approximate places I have shown. It doesn't have to be exact... I just go by eye, but you can do it mathematically if you want. Under the View menu, make sure snap to guides is on.
7.) Now you want to paint two lines along the vertical guidelines. Take care to start painting outside the image in the gray area. In other words, when you go to paint your line along the guideline, make sure your first click is entirely outside the image at the top, and do not let go of the mouse button until you are completely outside the image on the bottom. Your image should look pretty close to the one below.
8.) Now go to Image -> Rotate Canvas -> 90° CW. Again, paint a line along the vertical guidelines just as you did in the previous step.
Now you may go to the view menu and clear the guidelines.
9.) I want a smaller tile so I am going to resize this one down to 100 by 100 pixels (Image -> Image Size). By sizing it down, it makes the image a bit fuzzier, which enhances the look of flannel.
10.) To view the image as it would appear tiled, type Ctrl-A to Select All. Go to Edit -> Define Pattern. Open a new image, 500 by 500 pixels. Go to Edit -> Fill, and choose Pattern from the drop down box. Click OK and the new image is filled with your seamless tile.
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